BDBM50227999 (6S,7S)-7-hydroxycarbamoyl-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-spiro[2.5]octane-5-carboxylic acid methyl ester::CHEMBL404093

SMILES COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(C1)c1ccccc1)C(=O)NO

InChI Key InChIKey=VDWUMLKWSKKGLE-BSOSBYQFSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50227999   

LigandPNGBDBM50227999((6S,7S)-7-hydroxycarbamoyl-6-(3-phenyl-pyrrolidine...)
Affinity DataIC50:  81nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227999((6S,7S)-7-hydroxycarbamoyl-6-(3-phenyl-pyrrolidine...)
Affinity DataIC50:  289nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227999((6S,7S)-7-hydroxycarbamoyl-6-(3-phenyl-pyrrolidine...)
Affinity DataIC50: >5.00E+3nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed