BDBM50228518 (R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione::CHEMBL442078

SMILES C[C@@H]1CN(CCN1C(=O)C(=O)c1c[nH]c2ncccc12)C(=O)c1ccccc1

InChI Key InChIKey=CCGWWGUXCYXFJW-CQSZACIVSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50228518   

TargetCytochrome P450 1A2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50228518((R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyr...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50228518((R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyr...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of recombinant CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50228518((R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyr...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of recombinant CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50228518((R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyr...)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of human ERG by channel flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50228518((R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyr...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 using benzyloxy-4-(trifluoromethyl)coumarin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50228518((R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyr...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 using 7-benzyloxyresorufin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50228518((R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-pyr...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed