BDBM50230356 (3,4-DICHLOROPHENYL)(MORPHOLINO)METHANETHIONE

SMILES Clc1ccc(cc1Cl)C(=S)N1CCOCC1

InChI Key InChIKey=UGCXYBULZQHULY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50230356   

TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50230356((3,4-DICHLOROPHENYL)(MORPHOLINO)METHANETHIONE)
Affinity DataIC50:  1.91E+4nMAssay Description:Inhibition of PHGDH in human SiHa cells assessed as reduction in cell viability in serine repleted medium after 5 days by presto blue assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50230356((3,4-DICHLOROPHENYL)(MORPHOLINO)METHANETHIONE)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of recombinant human C-terminal His-tagged PHGDH (1 to 533 residues) expressed in Escherichia coli assessed as reduction in NADH formation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50230356((3,4-DICHLOROPHENYL)(MORPHOLINO)METHANETHIONE)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of PHGDH in human SiHa cells assessed as reduction in cell viability in serine depleted medium after 5 days by presto blue assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))TBA
LigandPNGBDBM50230356((3,4-DICHLOROPHENYL)(MORPHOLINO)METHANETHIONE)
Affinity DataIC50: <1.00E+6nMAssay Description:Inhibition of Homo sapiens (human) recombinant monoacylglycerol lipase assessed as inhibition of [3H]-2-oleolylglycerol hydrolysis after 10 min by li...More data for this Ligand-Target Pair
In DepthDetails Article
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50230356((3,4-DICHLOROPHENYL)(MORPHOLINO)METHANETHIONE)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of PHGDH in human HL60 cells assessed as reduction in cell viability in serine depleted medium after 5 days by presto blue assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50230356((3,4-DICHLOROPHENYL)(MORPHOLINO)METHANETHIONE)
Affinity DataIC50: <1.00E+6nMAssay Description:Inhibition of Homo sapiens (human) recombinant fatty acid amide hydrolase assessed as inhibition of [3H]-AEA hydrolysis after 10 min by liquid scinti...More data for this Ligand-Target Pair
In DepthDetails Article
TargetD-3-phosphoglycerate dehydrogenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50230356((3,4-DICHLOROPHENYL)(MORPHOLINO)METHANETHIONE)
Affinity DataIC50:  2.43E+4nMAssay Description:Inhibition of PHGDH in human HL60 cells assessed as reduction in cell viability in serine repleted medium after 5 days by presto blue assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed