BDBM50231790 CHEMBL4063532::US11725000, Compound 119

SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(cc2)C#N)c1

InChI Key InChIKey=XDZARUBGYJMGQY-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50231790   

TargetSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial(Homo sapiens (Human))
National Institute of Biological Sciences, Beijing

US Patent
LigandPNGBDBM50231790(CHEMBL4063532 | US11725000, Compound 119)
Affinity DataEC50:  5.50E+3nMAssay Description:In order to identify the target protein of tTC09 apoptosis inhibitors, we synthesized two sets of probes for target identification based on the SAR s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial(Homo sapiens (Human))
National Institute of Biological Sciences, Beijing

US Patent
LigandPNGBDBM50231790(CHEMBL4063532 | US11725000, Compound 119)
Affinity DataEC50:  3.49E+3nMAssay Description:Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed