BDBM50232504 (2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihydro[[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride::CHEMBL536089

SMILES CC1CN(C(C)c2nnc(n12)C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F

InChI Key InChIKey=VDLQLESOGPTTOL-NWGYLPEXSA-N

Data  28 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50232504   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50:  11nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXaa-Pro aminopeptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of amino peptidase PMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of QPPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of QPPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXaa-Pro aminopeptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of amino peptidase PMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50:  209nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXaa-Pro dipeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of prolidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXaa-Pro dipeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of prolidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of QPPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50:  12nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXaa-Pro dipeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of prolidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50:  11nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXaa-Pro aminopeptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of amino peptidase PMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of QPPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXaa-Pro aminopeptidase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of amino peptidase PMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXaa-Pro dipeptidase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of prolidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50232504((2R)-4-[5,8-dimethyl-3-(trifluoromethyl)-5,6-dihyd...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed