BDBM50232682 CHEMBL3467241::US11358936, Compound 2-7

SMILES NCc1ccnc(Oc2ccccc2)c1

InChI Key InChIKey=PJFOUMAUWJEBRT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50232682   

TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232682(CHEMBL3467241 | US11358936, Compound 2-7)
Affinity DataIC50:  309nMAssay Description:Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232682(CHEMBL3467241 | US11358936, Compound 2-7)
Affinity DataIC50:  310nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232682(CHEMBL3467241 | US11358936, Compound 2-7)
Affinity DataIC50:  650nMAssay Description:LOXL2 amine oxidase activity is evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells stably expr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232682(CHEMBL3467241 | US11358936, Compound 2-7)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-lysine 6-oxidase(Homo sapiens (Human))
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50232682(CHEMBL3467241 | US11358936, Compound 2-7)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50232682(CHEMBL3467241 | US11358936, Compound 2-7)
Affinity DataIC50:  310nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed