BDBM50233173 CHEMBL4094366::US11124490, Compound 14
SMILES Fc1cc(NC(=S)c2cc(c(Cl)cc2Cl)S(=O)(=O)N2CCOCC2)cc(F)c1F
InChI Key InChIKey=JNHWCHLGCVXZJP-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50233173
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
University Of Tennessee Health Science Center
Curated by ChEMBL
University Of Tennessee Health Science Center
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human C-terminal FLAg-tagged ATX lysophospholipase D activity expressed in baculovirus infected sf9 cells using FRET based ...More data for this Ligand-Target Pair
Affinity DataIC50: 35.3nMAssay Description:Compound 3b was found to be the most potent ATX inhibitor with an IC50 of about 9 nM. The mechanism of action was determined to be competitive; howev...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
University Of Tennessee Health Science Center
Curated by ChEMBL
University Of Tennessee Health Science Center
Curated by ChEMBL
Affinity DataIC50: 403nMAssay Description:Inhibition of ATX (unknown origin) expressed in human A2058 cells assessed as inhibition of LPC-induced cell invasion after 20 hrs by calcein-AM dye ...More data for this Ligand-Target Pair