BDBM50235587 CHEMBL4097246

SMILES FC(F)(F)c1cccc(NC(=O)Nc2nnc(SCc3nc4ccccc4[nH]c3=O)s2)c1

InChI Key InChIKey=XTKSMYZRQMTSMS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50235587   

TargetCyclin-C(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50235587(CHEMBL4097246)
Affinity DataIC50:  9nMAssay Description:Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/Cyclin C expressed in baculovirus expression system preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM50235587(CHEMBL4097246)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human full length TRKB expressed in CHO cells assessed as decrease in NGF-induced Ca2+ flux by Calcium 4 dye-based FLIPR TETRA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM50235587(CHEMBL4097246)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human full length TRKA expressed in CHO cells assessed as decrease in NGF-induced Ca2+ flux by Calcium 4 dye-based FLIPR TETRA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zoetis

Curated by ChEMBL
LigandPNGBDBM50235587(CHEMBL4097246)
Affinity DataIC50:  270nMAssay Description:Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed