BDBM50243388 AT-9283::US10981896, Compound AT9283
SMILES O=C(NC1CC1)Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1
InChI Key InChIKey=LOLPPWBBNUVNQZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50243388
Affinity DataKd: 11nMAssay Description:Binding affinity to N-terminal TEV-cleavable hexa-histidine tagged human JAK2 JH1 domain (840 to 1132 residues) expressed in baculovirus-infected Sf9...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of Aurora B kinase in human HCT116 cells assessed as reduction in polyploid phenotypeMore data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 685nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of Aurora B in human B-NHL cells assessed as inhibition of histone H3 phosphorylation on Ser10 by immunoblotting analysisMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Masaryk University
Curated by ChEMBL
Masaryk University
Curated by ChEMBL
Affinity DataIC50: 570nMAssay Description:Inhibition of DYRK2 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CDKL3 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 40 mins in presence of ATP by Kinase-glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 40 mins in presence of ATP by Kinase-glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of Aurora A (unknown origin) incubated for 40 mins in presence of ATP by Kinase-glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of Aurora B (unknown origin) incubated for 40 mins in presence of ATP by Kinase-glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of JAK 2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of JAK 3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Binding affinity towards rat beta adrenergic receptor from lung membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 685nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair