BDBM50244212 5-((4-(2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione::CHEMBL516479

SMILES CC(C)(C)c1ccc(cc1)-c1nc2c(cccc2[nH]1)N1CCN(Cc2c[nH]c(=O)[nH]c2=O)CC1

InChI Key InChIKey=GCTTXJNUVGNBBQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50244212   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50244212(5-((4-(2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  5.5nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from human recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50244212(5-((4-(2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  41nMAssay Description:Antagonist activity at recombinant GnRH receptor in CO2 asphyxiated rat primary pituitary cells assessed as reduction in (D-Trp6)LHRH-induced LH rele...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50244212(5-((4-(2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human recombinant GnRH receptor assessed as reduction in (D-Trp6)LHRH-induced myo-(1,2)-[3H]inositol productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50244212(5-((4-(2-(4-tert-Butylphenyl)-1H-benzo[d]imidazol-...)
Affinity DataIC50:  32nMAssay Description:Displacement of [125I]-(D-Trp6)LHRH from rat recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed