BDBM50245961 (1S,2R)-1-(2,3-dimethylphenoxy)-2-((methylamino)methyl)-2,3-dihydro-1H-inden-2-ol::CHEMBL461143

SMILES CNC[C@]1(O)Cc2ccccc2[C@@H]1Oc1cccc(C)c1C

InChI Key InChIKey=BLWMSZSENYHERE-RBUKOAKNSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50245961   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50245961((1S,2R)-1-(2,3-dimethylphenoxy)-2-((methylamino)me...)
Affinity DataIC50:  3nMAssay Description:Inhibition of norepinephrine uptake at human NET transfected in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50245961((1S,2R)-1-(2,3-dimethylphenoxy)-2-((methylamino)me...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50245961((1S,2R)-1-(2,3-dimethylphenoxy)-2-((methylamino)me...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of dopamine uptake at human DAT transfected in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50245961((1S,2R)-1-(2,3-dimethylphenoxy)-2-((methylamino)me...)
Affinity DataIC50:  50nMAssay Description:Inhibition of serotonin uptake at human SERT transfected in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed