BDBM50246289 3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)quinazolin-4(3H)-one::CHEMBL488248::CHEMBL557214

SMILES Cn1c(nc2ccccc2c1=O)-c1ccc(OCCCN2CCCC2)cc1

InChI Key InChIKey=PRPSMPHMELIHFQ-UHFFFAOYSA-N

Data  4 KI  7 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50246289   

TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataKi:  0.219nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataKi:  2.40nMAssay Description:Displacement of 3-([1,1,1-3H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone from mouse histamine H3 receptor expressed in HE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataKi:  4.20nMAssay Description:Binding affinity to human histamine H3 receptor by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataKi:  12nMAssay Description:Binding affinity to rat histamine H3 receptor by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50:  2.90E+3nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to mouse histamine H3 receptor overexpressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataKd:  3.10nMAssay Description:Binding affinity to histamine H3 receptor in wild type mouse brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataEC50:  9.60nMAssay Description:Inverse agonist activity at mouse histamine H3 receptor overexpressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50:  2.20E+3nMAssay Description:Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50:  2.90E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50:  0.680nMAssay Description:Inverse agonist activity at human histamine H3 receptor assessed as inhibition of R-alpha-methylhistamine-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50246289(3-methyl-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)q...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed