BDBM50248522 CHEMBL489332::N-hydroxy-3-(2-phenethyl-1-(2-(piperidin-1-yl)ethyl)-1H-benzo[d]imidazol-5-yl)acrylamide::US10201527, Compound 67::US10736881, Compound 67::US8551988, 67

SMILES ONC(=O)\C=C\c1ccc2n(CCN3CCCCC3)c(CCc3ccccc3)nc2c1

InChI Key InChIKey=XZWCFUZJOAZGAI-SDNWHVSQSA-N

Data  9 KI  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50248522   

TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248522(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Affinity DataIC50:  39nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone H3.1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248522(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Affinity DataEC50:  500nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248522(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Affinity DataIC50:  254nMAssay Description:To determine EC50 where acetylated histone 3 was induced by 50%, Colo205 cells was cultivated in 96 well plate at 1.5×105 cells/well for 24 h. Colo20...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248522(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Affinity DataIC50:  39nMAssay Description:The assay has been carried out in 96 well format and the BIOMOL fluorescent-based HDAC activity assay has been applied. The reaction composed of assa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248522(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Affinity DataIC50:  254nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248522(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Affinity DataIC50:  254nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Mei Pharma

US Patent
LigandPNGBDBM50248522(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Affinity DataIC50:  39nMAssay Description:The assay have been carried out in a 96 well format and the BIOMOL using a fluorescent-based HDAC activity assay.More data for this Ligand-Target Pair
In DepthDetails US Patent