BDBM50255062 CHEMBL465925::{3-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-phenyl]-pyridin-2-yl}-[4-(4-fluoro-benzyl)-piperidin-1-yl]-methanone

SMILES C[C@H]1CN(Cc2ccc(cc2)-c2cccnc2C(=O)N2CCC(Cc3ccc(F)cc3)CC2)C[C@@H](C)N1

InChI Key InChIKey=RLWXMWFCYVZNBY-ZRZAMGCNSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50255062   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255062(CHEMBL465925 | {3-[4-((3R,5S)-3,5-Dimethyl-piperaz...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMotilin receptor(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255062(CHEMBL465925 | {3-[4-((3R,5S)-3,5-Dimethyl-piperaz...)
Affinity DataEC50:  51nMAssay Description:Agonist activity at human GPR38 expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMotilin receptor(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255062(CHEMBL465925 | {3-[4-((3R,5S)-3,5-Dimethyl-piperaz...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human recombinant motilin receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255062(CHEMBL465925 | {3-[4-((3R,5S)-3,5-Dimethyl-piperaz...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using phenylpiperazinylmethylbenzylresofurin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed