BDBM50257156 (E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)thiophene-2-carboxamide::CHEMBL523684

SMILES ONC(=O)\C=C\c1ccc(s1)C(=O)Nc1cccc(Nc2ncc(s2)-c2cccnc2)c1

InChI Key InChIKey=IKGFSNOPTDDJGY-VQHVLOKHSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50257156   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257156((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(3-(4-...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of wild-type c-Abl (unknown origin) by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257156((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(3-(4-...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257156((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(3-(4-...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin) by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257156((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(3-(4-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257156((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(3-(4-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed