BDBM50257209 (E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)thiophene-2-carboxamide::CHEMBL493315

SMILES Cc1ccc(NC(=O)c2ccc(\C=C\C(=O)NO)s2)cc1Nc1ncc(s1)-c1cccnc1

InChI Key InChIKey=XSKZXGROFJZYER-VQHVLOKHSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50257209   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257209((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-met...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of wild-type c-Abl (unknown origin) by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257209((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-met...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257209((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-met...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin) by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257209((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-met...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50257209((E)-5-(3-(hydroxyamino)-3-oxoprop-1-enyl)-N-(4-met...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed