BDBM50257287 CHEMBL492309::Lys-Lys(epsilon-thioAc)-Leu

SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@@H](N)CCCCN)C(O)=O

InChI Key InChIKey=LKJCDGCUKQORAK-ULQDDVLXSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50257287   

TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50257287(CHEMBL492309 | Lys-Lys(epsilon-thioAc)-Leu)
Affinity DataIC50:  570nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) preincubated for 5 mins before addition of substrate measured after 1 hr by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50257287(CHEMBL492309 | Lys-Lys(epsilon-thioAc)-Leu)
Affinity DataIC50:  1.51E+5nMAssay Description:Inhibition of recombinant GST-tagged SIRT2 after 1 hr by Fluor de Lys-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50257287(CHEMBL492309 | Lys-Lys(epsilon-thioAc)-Leu)
Affinity DataIC50:  570nMAssay Description:Inhibition of recombinant GST-tagged SIRT1 after 1 hr by Fluor de Lys-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM50257287(CHEMBL492309 | Lys-Lys(epsilon-thioAc)-Leu)
Affinity DataIC50:  1.51E+5nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) preincubated for 5 mins before addition of substrate measured after 3 hrs by fluorescence-based assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed