BDBM50257405 Ala-Lys-Lys(epsilon-thioAc)Leu-Met::CHEMBL504711

SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(C)=S)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)N)C(O)=O

InChI Key InChIKey=IIESJRORKKINMK-SVXFZJLFSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257405   

TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50257405(Ala-Lys-Lys(epsilon-thioAc)Leu-Met | CHEMBL504711)
Affinity DataIC50:  380nMAssay Description:Inhibition of recombinant SIRT1 (unknown origin) preincubated for 5 mins before addition of substrate measured after 1 hr by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacylase sirtuin-6(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50257405(Ala-Lys-Lys(epsilon-thioAc)Leu-Met | CHEMBL504711)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of human recombinant SIRT6 assessed as 7-amino-4-methylcoumarin labelled Arg-His-Lys-Lys(epsilon-acetyl) substrate deacetylation after 90 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50257405(Ala-Lys-Lys(epsilon-thioAc)Leu-Met | CHEMBL504711)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of recombinant SIRT2 (unknown origin) preincubated for 5 mins before addition of substrate measured after 3 hrs by fluorescence-based assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed