BDBM50266786 CHEMBL4063337

SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)c1

InChI Key InChIKey=BKRZYDXKJLEFCP-CTHHTMFSSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50266786   

TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  110nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Mus musculus)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant mouse LOXL2 expressed in mouse whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of CYP2C9 human liver microsomes after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Rattus norvegicus)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  120nMAssay Description:Inhibition of rat LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-lysine 6-oxidase(Homo sapiens (Human))
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  74nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 3(Homo sapiens (Human))
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of recombinant human LOXL3 assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266786(CHEMBL4063337)
Affinity DataIC50:  710nMAssay Description:Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed