BDBM50267750 CHEMBL1078685

SMILES N#Cc1cc(ccn1)-c1n[nH]c(n1)-c1ccncc1

InChI Key InChIKey=UBVZQGOVTLIHLH-UHFFFAOYSA-N

Data  2 KI  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50267750   

TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50267750(CHEMBL1078685)
Affinity DataKi:  5.70nMAssay Description:Inhibition of xanthine oxidase (unknown origin)More data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
University Of Nis

Curated by ChEMBL
LigandPNGBDBM50267750(CHEMBL1078685)
Affinity DataKi:  5.70nMAssay Description:Competitive inhibition of bovine milk xanthine oxidoreductase assessed as reduction in uric acid formation by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Federal University Of Parana

Curated by ChEMBL
LigandPNGBDBM50267750(CHEMBL1078685)
Affinity DataIC50:  180nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human HEK293-A cells membrane vesicles assessed inhibition of ABCG2-mediated urate transport activi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
University Of Nis

Curated by ChEMBL
LigandPNGBDBM50267750(CHEMBL1078685)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of bovine milk xanthine oxidase using xanthine as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
University Of Nis

Curated by ChEMBL
LigandPNGBDBM50267750(CHEMBL1078685)
Affinity DataIC50:  21nMAssay Description:Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 10 mins followed by s...More data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
University Of Nis

Curated by ChEMBL
LigandPNGBDBM50267750(CHEMBL1078685)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of bovine milk xanthine oxidoreductase assessed as reduction in conversion of xanthine to uric acid by spectrophotometryMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
University Of Nis

Curated by ChEMBL
LigandPNGBDBM50267750(CHEMBL1078685)
Affinity DataIC50:  15nMAssay Description:Antagonistic activity against the P2X7 ion channelMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
University Of Nis

Curated by ChEMBL
LigandPNGBDBM50267750(CHEMBL1078685)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair