BDBM50270877 (R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide::ABT-263::CHEMBL443684::US11318134, Example ABT-263::US11344546, Example ABT-263::US11420968, Example ABT-263::US11590126, Example ABT-263
SMILES CC1(C)CCC(=C(CN2CCN(CC2)c2ccc(cc2)C(=O)NS(=O)(=O)c2ccc(N[C@H](CCN3CCOCC3)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)C1)c1ccc(Cl)cc1
InChI Key InChIKey=JLYAXFNOILIKPP-KXQOOQHDSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50270877
Affinity DataKi: 0.0440nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.0550nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: <0.100nMAssay Description:Inhibition of F-Bak binding to GST-tagged BCL2 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: <0.100nMAssay Description:Inhibition of F-Bak binding to GST-tagged BCL-XL (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Abbvie
Curated by ChEMBL
Abbvie
Curated by ChEMBL
Affinity DataKi: >224nMAssay Description:Inhibition of F-Bak binding to GST-tagged MCL1 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair