BDBM50271804 CHEMBL504416::N4-(3-Chloro-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

SMILES Nc1nc(Nc2ccc(F)c(Cl)c2)c2cc(CCc3ccccc3)[nH]c2n1

InChI Key InChIKey=YQKMPOKWRHBWLE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50271804   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271804(CHEMBL504416 | N4-(3-Chloro-4-fluorophenyl)-6-(2-p...)
Affinity DataIC50:  2.28E+4nMAssay Description:Inhibition of EGFR (unknown origin) expressed in human tumor cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271804(CHEMBL504416 | N4-(3-Chloro-4-fluorophenyl)-6-(2-p...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of PDGFRbeta (unknown origin) expressed in human tumor cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271804(CHEMBL504416 | N4-(3-Chloro-4-fluorophenyl)-6-(2-p...)
Affinity DataIC50:  1.32E+5nMAssay Description:Inhibition of VEGFR2 (unknown origin) expressed in human tumor cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50271804(CHEMBL504416 | N4-(3-Chloro-4-fluorophenyl)-6-(2-p...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of VEGFR1 (unknown origin) expressed in human tumor cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed