BDBM50272645 CHEMBL445082::N-methyl((3R,4R)-4-(o-tolyloxy)-3,4-dihydro-2H-chromen-3-yl)methanamine::N-methyl((3R,4R)-4-(o-tolyloxy)chroman-3-yl)methanamine

SMILES CNC[C@@H]1COc2ccccc2[C@@H]1Oc1ccccc1C

InChI Key InChIKey=AROKURNCLIVVKP-RDTXWAMCSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50272645   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272645(CHEMBL445082 | N-methyl((3R,4R)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272645(CHEMBL445082 | N-methyl((3R,4R)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  26nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272645(CHEMBL445082 | N-methyl((3R,4R)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272645(CHEMBL445082 | N-methyl((3R,4R)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of recombinant CYP32D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272645(CHEMBL445082 | N-methyl((3R,4R)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272645(CHEMBL445082 | N-methyl((3R,4R)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272645(CHEMBL445082 | N-methyl((3R,4R)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  40nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed