BDBM50272646 CHEMBL525375::N-methyl((1R,2S)-1-(o-tolyloxy)-1,2,3,4-tetrahydronaphthalen-2-yl)methanamine

SMILES CNC[C@@H]1CCc2ccccc2[C@@H]1Oc1ccccc1C

InChI Key InChIKey=CBIWVBLPTDWHKB-QFBILLFUSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50272646   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272646(CHEMBL525375 | N-methyl((1R,2S)-1-(o-tolyloxy)-1,2...)
Affinity DataIC50:  40nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272646(CHEMBL525375 | N-methyl((1R,2S)-1-(o-tolyloxy)-1,2...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272646(CHEMBL525375 | N-methyl((1R,2S)-1-(o-tolyloxy)-1,2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272646(CHEMBL525375 | N-methyl((1R,2S)-1-(o-tolyloxy)-1,2...)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant CYP32D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272646(CHEMBL525375 | N-methyl((1R,2S)-1-(o-tolyloxy)-1,2...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272646(CHEMBL525375 | N-methyl((1R,2S)-1-(o-tolyloxy)-1,2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272646(CHEMBL525375 | N-methyl((1R,2S)-1-(o-tolyloxy)-1,2...)
Affinity DataIC50:  7nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed