BDBM50272690 CHEMBL497461::N-methyl((3R,4S)-4-(o-tolyloxy)-3,4-dihydro-2H-chromen-3-yl)methanamine

SMILES CNC[C@@H]1COc2ccccc2[C@H]1Oc1ccccc1C

InChI Key InChIKey=AROKURNCLIVVKP-KDOFPFPSSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50272690   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272690(CHEMBL497461 | N-methyl((3R,4S)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  420nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272690(CHEMBL497461 | N-methyl((3R,4S)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of recombinant CYP32D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272690(CHEMBL497461 | N-methyl((3R,4S)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272690(CHEMBL497461 | N-methyl((3R,4S)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed