BDBM50272717 CHEMBL505433::N-methyl((3S,4S)-4-(o-tolyloxy)-3,4-dihydro-1H-isochromen-3-yl)methanamine::N-methyl((3S,4S)-4-(o-tolyloxy)isochroman-3-yl)methanamine

SMILES CNC[C@@H]1OCc2ccccc2[C@@H]1Oc1ccccc1C

InChI Key InChIKey=FHNHVNKWEHYJDJ-ROUUACIJSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50272717   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(CHEMBL505433 | N-methyl((3S,4S)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(CHEMBL505433 | N-methyl((3S,4S)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  18nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(CHEMBL505433 | N-methyl((3S,4S)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(CHEMBL505433 | N-methyl((3S,4S)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant CYP32D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(CHEMBL505433 | N-methyl((3S,4S)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  900nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(CHEMBL505433 | N-methyl((3S,4S)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272717(CHEMBL505433 | N-methyl((3S,4S)-4-(o-tolyloxy)-3,4...)
Affinity DataIC50:  5nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed