BDBM50272730 ((3S,4S)-4-(2-fluoro-6-(trifluoromethyl)phenoxy)-3,4-dihydro-1H-isochromen-3-yl)-N-methylmethanamine::CHEMBL497512

SMILES CNC[C@@H]1OCc2ccccc2[C@@H]1Oc1c(F)cccc1C(F)(F)F

InChI Key InChIKey=ULFUJAQEYUFVSH-HOTGVXAUSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50272730   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272730(((3S,4S)-4-(2-fluoro-6-(trifluoromethyl)phenoxy)-3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272730(((3S,4S)-4-(2-fluoro-6-(trifluoromethyl)phenoxy)-3...)
Affinity DataIC50:  4nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272730(((3S,4S)-4-(2-fluoro-6-(trifluoromethyl)phenoxy)-3...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272730(((3S,4S)-4-(2-fluoro-6-(trifluoromethyl)phenoxy)-3...)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant CYP32D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272730(((3S,4S)-4-(2-fluoro-6-(trifluoromethyl)phenoxy)-3...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272730(((3S,4S)-4-(2-fluoro-6-(trifluoromethyl)phenoxy)-3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272730(((3S,4S)-4-(2-fluoro-6-(trifluoromethyl)phenoxy)-3...)
Affinity DataIC50:  4nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed