BDBM50272747 ((3S,4S)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chromen-3-yl)-N-methylmethanamine::CHEMBL452429

SMILES CNC[C@H]1COc2ccccc2[C@H]1Oc1ccccc1Cl

InChI Key InChIKey=DZEOBMAMUUMJNJ-SJCJKPOMSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50272747   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272747(((3S,4S)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chrome...)
Affinity DataIC50:  230nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272747(((3S,4S)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chrome...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant CYP32D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272747(((3S,4S)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chrome...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272747(((3S,4S)-4-(2-chlorophenoxy)-3,4-dihydro-2H-chrome...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed