BDBM50295540 CHEMBL561788::N-(2-phenylcyclopropyl)-4-(3-(2-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide

SMILES FC(F)(F)c1ccccc1-c1noc(n1)C1CCN(CC1)C(=O)NC1CC1c1ccccc1

InChI Key InChIKey=AEUILRDAXLSTHQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50295540   

TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295540(CHEMBL561788 | N-(2-phenylcyclopropyl)-4-(3-(2-(tr...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295540(CHEMBL561788 | N-(2-phenylcyclopropyl)-4-(3-(2-(tr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat sEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295540(CHEMBL561788 | N-(2-phenylcyclopropyl)-4-(3-(2-(tr...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human sEH in HEK293 cells assessed as conversion of 14,15-epoxyeicosatrienoic acid to 14,15-dihydroepoxyeicosatrienoic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295540(CHEMBL561788 | N-(2-phenylcyclopropyl)-4-(3-(2-(tr...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human mEHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295540(CHEMBL561788 | N-(2-phenylcyclopropyl)-4-(3-(2-(tr...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of IKr channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295540(CHEMBL561788 | N-(2-phenylcyclopropyl)-4-(3-(2-(tr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295540(CHEMBL561788 | N-(2-phenylcyclopropyl)-4-(3-(2-(tr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295540(CHEMBL561788 | N-(2-phenylcyclopropyl)-4-(3-(2-(tr...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Cav 1.2 channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50295540(CHEMBL561788 | N-(2-phenylcyclopropyl)-4-(3-(2-(tr...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed