BDBM50296173 (+/-)-1-{3-[4-(6-Methoxy-3-methyl-4,4-dioxo-3,4-dihydro-2H-4lambda*6*-benzo[1,4]oxathiin-2-yl)-phenoxy]-propyl}-pyrrolidine::CHEMBL565007

SMILES COc1ccc2OC(C(C)S(=O)(=O)c2c1)c1ccc(OCCCN2CCCC2)cc1

InChI Key InChIKey=YZSDHSPCNCYZKJ-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50296173   

TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50296173((+/-)-1-{3-[4-(6-Methoxy-3-methyl-4,4-dioxo-3,4-di...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50296173((+/-)-1-{3-[4-(6-Methoxy-3-methyl-4,4-dioxo-3,4-di...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50296173((+/-)-1-{3-[4-(6-Methoxy-3-methyl-4,4-dioxo-3,4-di...)
Affinity DataIC50:  0.400nMAssay Description:Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of R-alpha-methylistamine-induced [35S]GTPgammaS binding by cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50296173((+/-)-1-{3-[4-(6-Methoxy-3-methyl-4,4-dioxo-3,4-di...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of [35S]MK499 binding to human ERG transfected in HEK293 cells by microscintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed