BDBM50296914 (1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-isopropyl-1-(6-methylpyridin-3-yl)-1H-imidazol-4-yl)methyl)-3-fluorocyclopentanamine::CHEMBL561397

SMILES CC(C)c1c(CN[C@H]2CC[C@@H](F)C2)nc(-c2ncccc2Cl)n1-c1ccc(C)nc1

InChI Key InChIKey=QDXKTBFIOVZINL-SJORKVTESA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296914   

TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296914((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-isopropyl-1...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296914((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-isopropyl-1...)
Affinity DataIC50:  1.50E+4nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cells overexpressing Ikr channel proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50296914((1S,3R)-N-((2-(3-chloropyridin-2-yl)-5-isopropyl-1...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at human cloned ORL1 receptor expressed in CHO cells assessed as inhibition of nociceptin/orphanin FQ-stimulated [35S]GTPgammaS b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed