BDBM50300119 (2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((R)-3,4-dihydroxybutyl)-5-fluoro-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide::CHEMBL576342

SMILES CC(C)(C)C[C@H]1N[C@H]([C@H](c2cccc(Cl)c2)[C@@]11C(=O)Nc2cc(Cl)c(F)cc12)C(=O)NCC[C@@H](O)CO

InChI Key InChIKey=UNXQGBMZYKHQCO-LZITZJIASA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50300119   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  12.6nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  13nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  13nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataIC50:  157nMAssay Description:Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed