BDBM50300958 3-(2-(2-hydroxyethylamino)ethylamino)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL567252

SMILES CCCOCCn1c2cc(ncc2nc(NCCNCCO)c1=O)-c1ccc(OC)nc1

InChI Key InChIKey=CPYDGVQEYKJGKY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50300958   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300958(3-(2-(2-hydroxyethylamino)ethylamino)-7-(6-methoxy...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300958(3-(2-(2-hydroxyethylamino)ethylamino)-7-(6-methoxy...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human ERG by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50300958(3-(2-(2-hydroxyethylamino)ethylamino)-7-(6-methoxy...)
Affinity DataIC50:  272nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50300958(3-(2-(2-hydroxyethylamino)ethylamino)-7-(6-methoxy...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human platelet PDE5 assessed as reduction in conversion of [3H]cGMP to [3H]GMP after 2 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed