BDBM50302098 3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide::CHEMBL577075

SMILES CCN(CC)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O

InChI Key InChIKey=OXXWFUQKMJSKBO-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50302098   

TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302098(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Affinity DataKi:  120nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302098(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Affinity DataKi:  9.70E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302098(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Affinity DataIC50:  1.86E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302098(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Affinity DataIC50:  0.120nMAssay Description:Antagonist activity at CXCR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302098(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Affinity DataIC50:  46nMAssay Description:Antagonist activity at CXCR2 expressed in CHO cells assessed as inhibition of IL-8-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed