BDBM50303770 (E/Z)-6,7-Dichloro-3-(3,5-dibromo-4-hydroxybenzylidene)-indolin-2-one::CHEMBL569449

SMILES Oc1c(Br)cc(\C=C2/C(=O)Nc3c2ccc(Cl)c3Cl)cc1Br

InChI Key InChIKey=XXEUCGGVUVJTEB-BAQGIRSFSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50303770   

TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris A Gsk

Curated by ChEMBL
LigandPNGBDBM50303770((E/Z)-6,7-Dichloro-3-(3,5-dibromo-4-hydroxybenzyli...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of SIRT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk

Curated by ChEMBL
LigandPNGBDBM50303770((E/Z)-6,7-Dichloro-3-(3,5-dibromo-4-hydroxybenzyli...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of SIRT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ludwig-Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50303770((E/Z)-6,7-Dichloro-3-(3,5-dibromo-4-hydroxybenzyli...)
Affinity DataIC50:  4.06E+4nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged SIRT1 after 4 hrs in presence of NAD+ by fluorescent deacetyalse assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris A Gsk

Curated by ChEMBL
LigandPNGBDBM50303770((E/Z)-6,7-Dichloro-3-(3,5-dibromo-4-hydroxybenzyli...)
Affinity DataIC50:  2.36E+4nMAssay Description:Inhibition of human recombinant N-terminally 6X-His-tagged SIRT3 after 4 hrs in presence of NAD+ by fluorescent deacetyalse assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk

Curated by ChEMBL
LigandPNGBDBM50303770((E/Z)-6,7-Dichloro-3-(3,5-dibromo-4-hydroxybenzyli...)
Affinity DataIC50:  2.84E+4nMAssay Description:Inhibition of human recombinant N-terminally 6X-His-tagged SIRT2 after 4 hrs in presence of NAD+ by fluorescent deacetyalse assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ludwig-Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50303770((E/Z)-6,7-Dichloro-3-(3,5-dibromo-4-hydroxybenzyli...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of SIRT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed