BDBM50305207 4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime::CHEMBL593902

SMILES CC(N=O)C(C)=Cc1ccc(Cl)cc1

InChI Key InChIKey=KKWDVPSRWHSHCQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50305207   

LigandPNGBDBM50305207(4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime | ...)
Affinity DataIC50:  2.80E+3nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate countMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305207(4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime | ...)
Affinity DataIC50:  2.20E+3nMAssay Description:Antagonist activity at human TRPA1 expressed in human IMR90 cells assessed as inhibition of acrolein-induced calcium influx after 40 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50305207(4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime | ...)
Affinity DataIC50:  3.40E+3nMAssay Description:Antagonist activity at Sprague-Dawley rat TRPA1 expressed in rat DRG neurons assessed as inhibition of acrolein-induced calcium influx after 40 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305207(4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime | ...)
Affinity DataIC50:  3.10E+3nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO cells assessed as inhibition of CA-induced increase in calcium influx by Fluo-4 dye based FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Mus musculus)
Ferrara University

Curated by ChEMBL
LigandPNGBDBM50305207(4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime | ...)
Affinity DataIC50:  4.50E+3nMAssay Description:Antagonist activity at mouse TRPA1 channel expressed in CHO cells assessed as inhibition of cinnamaldehyde-induced intracellular calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305207(4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime | ...)
Affinity DataIC50:  4.47E+3nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of CA-induced increase in calcium influx incubated for 10 mins pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305207(4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime | ...)
Affinity DataIC50:  4.46E+3nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of CA-induced increase in calcium influx incubated for 10 mins pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50305207(4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime | ...)
Affinity DataIC50:  3.10E+3nMAssay Description:Antagonist activity at human TRPA1 channel expressed in CHO cells assessed as inhibition of cinnamaldehyde-induced intracellular calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed