BDBM50308199 2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one::CHEMBL605118

SMILES CCOc1ccc(Nc2ncc3CC(=O)Nc4ccncc4-c3n2)cc1

InChI Key InChIKey=CMNMWXJPOUQMBC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50308199   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308199(2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]py...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308199(2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]py...)
Affinity DataIC50:  99nMAssay Description:Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308199(2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]py...)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of VEGFR2 in HUE cells assessed as inhibition of VEGF-induced autophosphorylation treated for 90 mins before VEGF challenge by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308199(2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]py...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed