BDBM50308200 2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one::CHEMBL602043

SMILES Oc1cccc(Nc2ncc3CC(=O)Nc4ccncc4-c3n2)c1

InChI Key InChIKey=NFBRGEFBURVIHX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50308200   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308200(2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]p...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of PLK1 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308200(2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]p...)
Affinity DataIC50:  140nMAssay Description:Inhibition of VEGFR2 assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Technische Universitat Braunschweig

Curated by ChEMBL
LigandPNGBDBM50308200(2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of INSR assessed as [33Pi] incorporation by microplate scintillation counting in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed