BDBM50311463 4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-methyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrolo[3,2-d]pyridazine-2-carboxamide::CHEMBL1081849

SMILES CN1CCN(CCCNC(=O)c2[nH]c3cnnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2C)CC1

InChI Key InChIKey=LREJPDVGVCQBEA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50311463   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311463(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50:  2.24E+3nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311463(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311463(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50:  980nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed