BDBM50312155 1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)urea::CHEMBL1079846

SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F

InChI Key InChIKey=VDQZIQXNPVFCAD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50312155   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  7nMAssay Description:Inhibition of VEGFR2 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  37nMAssay Description:Inhibition of EphB4 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Tie2 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  50nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  100nMAssay Description:Inhibition of VEGFR2 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312155(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Tie2 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed