BDBM50312685 (S)-2-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)thiazole-5-carboxamide::CHEMBL1081255

SMILES NC(=O)c1cnc(s1)N1CC[C@@H](C1)Oc1ccccc1C(F)(F)F

InChI Key InChIKey=NDZZWAAUFMRWHJ-VIFPVBQESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50312685   

TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312685((S)-2-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-...)
Affinity DataIC50:  84nMAssay Description:Inhibition of SCD1 in human HepG2 cells assessed as [14C]stearic acid to [14C]oleic acid conversion pretreated 15 mins before [14C]stearic acid addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50312685((S)-2-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed