BDBM50314753 6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpyrazol-4-yl]carbonyl}amino)ethyl]pyridine-3-carboxamide::CHEMBL1089498

SMILES CCOc1ccc(cn1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccc1

InChI Key InChIKey=PBFHWAXLKCTDCS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50314753   

TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314753(6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  87nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314753(6-Ethoxy-N-[2-({[1-phenyl-3-(trifluoromethyl)-1Hpy...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed