BDBM50316562 2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1H-indazol-5-yl)-1-hydroxyethyl)benzonitrile::CHEMBL1094536::CHEMBL1096467

SMILES OC(c1ccc(F)c(c1)C#N)(c1ccc2n(ncc2c1)-c1ccc(F)cc1)C(F)(F)F

InChI Key InChIKey=DXRCWRDHBIVBIS-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50316562   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316562(2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...)
Affinity DataIC50:  30nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316562(2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316562(2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...)
Affinity DataEC50:  112nMAssay Description:Agonist activity at glucocorticoid receptor in human fibroblast assessed as inhibition of IL-1-beta-induced IL6 production treated 1 hr before IL1-be...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50316562(2-chloro-4-(2,2,2-trifluoro-1-(1-(4-fluorophenyl)-...)
Affinity DataIC50:  54nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polariztion competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed