BDBM50324319 1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine::CHEMBL1214932

SMILES C1CN(CCN1)c1nc(cc2cnccc12)-c1ccncc1

InChI Key InChIKey=GVSRILDMSGVJTR-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50324319   

TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of PKD1 assessed as HDAC5 neuclear exportMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of PKCalpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Affinity DataIC50:  59nMAssay Description:Inhibition of PKD1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human PKCalpha assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Affinity DataIC50:  109nMAssay Description:Inhibition of recombinant human PKCtheta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Affinity DataIC50:  31nMAssay Description:Inhibition of PKCdelta by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Affinity DataIC50:  823nMAssay Description:Inhibition of recombinant human PKCbeta1 assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Affinity DataIC50:  31nMAssay Description:Inhibition of recombinant human PKCdelta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human PKCepsilon assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50324319(1-Piperazin-1-yl-3-pyridin-4-yl[2,6]naphthyridine ...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human PKCeta assessed as [33P]-ATP incorporation into tridecapeptide substrate after 60 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed