BDBM50327009 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide::4-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]amino}-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide::CHEMBL1230065

SMILES CCCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NC3CC3)c2c1C

InChI Key InChIKey=GDTQLZHHDRRBEB-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50327009   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50327009(4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5...)
Affinity DataIC50:  13nMAssay Description:Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 minsMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50327009(4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50327009(4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50327009(4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5...)
Affinity DataIC50:  13nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50327009(4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50327009(4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327009(4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5...)
Affinity DataIC50:  62nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50327009(4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed