BDBM50327391 CHEMBL1258976::N1-(4-(2-chlorophenyl)-6-(2-(isopropylamino)thiazol-5-yl)pyrimidin-2-yl)-N2,N2-dimethylethane-1,2-diamine

SMILES CC(C)Nc1ncc(s1)-c1cc(nc(NCCN(C)C)n1)-c1ccccc1Cl

InChI Key InChIKey=WTRQXHALVSEXHZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50327391   

TargetLIM domain kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327391(CHEMBL1258976 | N1-(4-(2-chlorophenyl)-6-(2-(isopr...)
Affinity DataIC50:  4.01nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327391(CHEMBL1258976 | N1-(4-(2-chlorophenyl)-6-(2-(isopr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50327391(CHEMBL1258976 | N1-(4-(2-chlorophenyl)-6-(2-(isopr...)
Affinity DataIC50:  3.05nMAssay Description:Inhibition of LIMK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed