BDBM50330266 4-(3-Isopropyl-1H-pyrazol-4-yl)-N-(5-(piperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine::CHEMBL1271564

SMILES CC(C)c1[nH]ncc1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1

InChI Key InChIKey=MKJQNJOYGXZGII-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50330266   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330266(4-(3-Isopropyl-1H-pyrazol-4-yl)-N-(5-(piperazin-1-...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human CDK4/cyclin D1 expressed in baculovirus infected Sf21 cells after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330266(4-(3-Isopropyl-1H-pyrazol-4-yl)-N-(5-(piperazin-1-...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of human CDK2/cyclin A after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330266(4-(3-Isopropyl-1H-pyrazol-4-yl)-N-(5-(piperazin-1-...)
Affinity DataIC50:  5.58E+3nMAssay Description:Inhibition of human CDK1/cyclin B after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330266(4-(3-Isopropyl-1H-pyrazol-4-yl)-N-(5-(piperazin-1-...)
Affinity DataIC50:  451nMAssay Description:Inhibition of CDK4 in human Jeko1 cells assessed as phosphorylated pRb at Ser780 level after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330266(4-(3-Isopropyl-1H-pyrazol-4-yl)-N-(5-(piperazin-1-...)
Affinity DataIC50:  591nMAssay Description:Inhibition of CDK4 in human Jeko1 cells assessed as phosphorylated pRb at Ser780 level after 2 hrs by ELISA relative to total pRb levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed