BDBM50330271 CHEMBL1271620::[4-(3-Isopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-(4-piperazin-1-yl-phenyl)-amine

SMILES CC(C)c1[nH]ncc1-c1ccnc(Nc2ccc(cc2)N2CCNCC2)n1

InChI Key InChIKey=GNGCBEUJIURHCQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50330271   

TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330271(CHEMBL1271620 | [4-(3-Isopropyl-1H-pyrazol-4-yl)-p...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human CDK2/cyclin A after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330271(CHEMBL1271620 | [4-(3-Isopropyl-1H-pyrazol-4-yl)-p...)
Affinity DataIC50:  71nMAssay Description:Inhibition of human CDK1/cyclin B after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330271(CHEMBL1271620 | [4-(3-Isopropyl-1H-pyrazol-4-yl)-p...)
Affinity DataIC50: <5nMAssay Description:Inhibition of human CDK4/cyclin D1 expressed in baculovirus infected Sf21 cells after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed