BDBM50332491 (E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)thiophen-2-yl)-N-hydroxyacrylamide::CHEMBL1630108

SMILES ONC(=O)\C=C\c1ccc(s1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1

InChI Key InChIKey=SUBNLERWESOYMX-YRNVUSSQSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50332491   

TargetInsulin receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of INSR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50: >3.20E+4nMAssay Description:Inhibition of Flag tagged human recombinant HDAC3 expressed in Sf21 cells coexpressing SMRT DAD domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant HDAC6 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of Flag tagged human recombinant HDAC8 expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of EGFR by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of PLK1 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of PDGFRbeta by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of ABL1 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  440nMAssay Description:Inhibition of CDK2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of human recombinant HDAC1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50332491((E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenyla...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of HER2 by flash plate based radioactive enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed