BDBM50337325 5-(3-benzylisoxazol-5-yl)-1H-indazol-3-amine::CHEMBL1682358

SMILES Nc1n[nH]c2ccc(cc12)-c1cc(Cc2ccccc2)no1

InChI Key InChIKey=XFHCSNRQFQRLHZ-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50337325   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337325(5-(3-benzylisoxazol-5-yl)-1H-indazol-3-amine | CHE...)
Affinity DataKi:  16nMAssay Description:Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337325(5-(3-benzylisoxazol-5-yl)-1H-indazol-3-amine | CHE...)
Affinity DataKi:  16nMAssay Description:Inhibition of JAK2 after 1 hr using biotinylated PDKtide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337325(5-(3-benzylisoxazol-5-yl)-1H-indazol-3-amine | CHE...)
Affinity DataKi:  26nMAssay Description:Inhibition of Aurora kinase 2 after 1 hr using biotinylated kemptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337325(5-(3-benzylisoxazol-5-yl)-1H-indazol-3-amine | CHE...)
Affinity DataKi:  450nMAssay Description:Inhibition of GSK3-beta after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337325(5-(3-benzylisoxazol-5-yl)-1H-indazol-3-amine | CHE...)
Affinity DataKi:  3.29E+3nMAssay Description:Inhibition of KDR after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337325(5-(3-benzylisoxazol-5-yl)-1H-indazol-3-amine | CHE...)
Affinity DataKi:  3.59E+3nMAssay Description:Inhibition of Pak4 after 1 hr using biotinylated L15 peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50337325(5-(3-benzylisoxazol-5-yl)-1H-indazol-3-amine | CHE...)
Affinity DataKi:  5.16E+3nMAssay Description:Inhibition of Pim1 after 1 hr using biotinylated AL1peptide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed